Background: The extent of cortical pathology is an important determinant of multiple sclerosis (MS) severity. Cortical demyelination and neurodegeneration are related to inflammation of the overlying ...

Citrate blood was taken from 18 healthy volunteers by brachial vein puncture and anti-adenoviral antibody titers were determined by ELISA, complement fixation test (CBR) and neutralizing assay.

Autoimmune bullous dermatoses (AIBD) are characterized by circulating autoantibodies that are either directed against epidermal antigens or deposited as immune complexes in the basement membrane zone ...

Lobsiger et al. (1) recently demonstrated that superoxide dismutase 1 (SOD1) transgenic mice deficient in complement components C1q and C3 do not have extended survival, concluding that global ...

Complement activation in paroxysmal nocturnal hemoglobinuria (PNH) only leads to strong prothrombotic cell activation when it triggers membrane attack complex (MAC)-mediated cytolysis and subsequent ...

The classical pathway of complement is activated when C1 binds to surface-bound antibody complexes. Antibody-mediated complement activation may lead to cell lysis (CDC) or lead to 'silent' ...