This is a summary of: Liu. H. et al. Viral RNA blocks circularization to evade host codon usage control. Nature https://doi.org/10.1038/s41586-025-09809-y (2025).

Scientists have identified a microbe capable of interpreting a single piece of genetic code in two completely different ways, ...

A research team has developed DeepCodon, a deep learning–based codon optimization tool that significantly improves heterologous protein expression in Escherichia coli while preserving functionally ...

The choice of codons can influence local translation kinetics during protein synthesis. Whether codon preference is linked to cotranslational regulation of polypeptide folding remains unclear. Here, ...

Highly expressed genes are encoded by codons that correspond to abundant tRNAs, a phenomenon thought to ensure high expression levels. An alternative interpretation is that highly expressed genes are ...

Codon usage analysis is a crucial part of molecular characterization and is used to determine the factors affecting the evolution of a gene. The length of a gene is an important parameter that affects ...

Methods for analysing correlated mutations in proteins are becoming an increasingly powerful tool for predicting contacts within and between proteins. Nevertheless, limitations remain due to the ...

Selective transcription of individual protein coding genes does not occur in trypanosomes and the cellular copy number of each mRNA must be determined post-transcriptionally. Here, we provide evidence ...

Researchers discover a unique genetic code in Antarctic archaea that encodes a rare amino acid, potentially advancing protein ...

For decades, biology has relied on one central assumption: the genetic code is precise. DNA is transcribed into RNA, RNA is ...

This program is used to display, modify, and compare the codons of gene. It shows the codons and GC content of the gene in the form of visual graphics, and the user can modify the codons to optimize ...