All models minimize the Negative Sampling objective as proposed by T. Mikolov et al. [1]. This provides scope for sparse updates (i.e. only vectors of sampled noise words are used in forward and ...

The use of viral vectors to deliver genes to the nervous system shows great promise for both basic research and therapeutic applications. However, the brain presents a challenging target for gene ...

Translating knowledge of genetic disease mechanisms into gene therapies has been slow with limited clinical success. One major reason is that the transfer vectors, which are most often of viral origin ...