Outcome-adaptive randomization is one of the possible elements of an adaptive trial design in which the ratio of patients randomly assigned to the experimental treatment arm versus the control ...

Randomization have proven to be an efficient way of reducing bias and thus is widely used in clinical trials. Randomization ensures that subject allocation is balanced across treatment group and is ...

Response-adaptive designs allow the randomization probabilities to change during the course of a trial based on cumulated response data so that a greater proportion of patients can be allocated to the ...