Cholera is a disease of poverty affecting people with inadequate access to safe water and basic sanitation. Conflict, unplanned urbanization and climate change all increase the risk of cholera. In ...

Abstract: A mathematical model for tumor anti-angiogenesis that was formulated and biologically validated by Hahnfeldt et al. is considered as an optimal control problem. In earlier research, the ...

Abstract: An optimal control problem for a class of nonlinear distributed parameter systems is posed. By using a theorem of approximation theory, necessary and sufficient conditions upon the optimal ...

The release of tumor antigens during traditional cancer treatments such as radio- or chemotherapy leads to a stimulation of the immune response which provides synergistic effects these treatments have ...

Optimal control theory for differential equations is a pivotal discipline that combines rigorous mathematical analysis with practical applications in engineering, economics, and the natural sciences.

Note: MILP solvers return globally optimal solutions but their runtimes can be unpredictable; conversely, coordinate exchange algorithms are not gauranteed to be globally optimal but scale more ...

ABSTRACT: In this paper, Homotopy perturbation method is used to find the approximate solution of the optimal control of linear systems. In this method the initial approximations are freely chosen, ...

ABSTRACT: In order to decrease the fluid drag on an underwater robot manipulator, an optimal trajectory method based on the variational method is presented. By introducing the adjoint variables, which ...