The nucleolus is an organelle in the nucleus that plays a key role in the transcription and processing of ribosomal RNA (rRNA). While many studies have highlighted the viscoelastic material state of ...

The multicopy ribosomal DNA (rDNA) array gives origin to the nucleolus, a large nonmembrane-bound organelle that occupies a substantial volume within the cell nucleus. The rDNA/nucleolus has emerged ...

When cells are observed by phase contrast microscopy, nucleoli are among the most conspicuous structures. The nucleolus was formally described between 1835 and 1839, but it was another century before ...

A nucleolar protein, nucleostemin, is now implicated in the control of stem and cancer cell proliferation. Nucleostemin may modulate p53 function through shuttling between the nucleolus and the ...

How membraneless organelles like nucleolus assemble within cells is not well understood. Recent experiments suggest that transcription of ribosomal RNA actively drives nucleolar assembly. Our proposed ...

The nucleolus—a conspicuous but obscure organelle within the cell nucleus—is normally too compact to be studied in detail. Researchers at Case Western Reserve University just learned how to simplify ...

Viruses are suspected of significant roles in autoimmune diseases but the mechanisms are unclear. We get some insight by considering demands a virus places on host cells. Viruses not only require ...

The size of a cell's nucleolus may reveal how long that cell, or even the organism it belongs to, will live. Over the past few years, researchers have been piecing together an unexpected link between ...

1 Department of Cardiovascular Surgery, Taizhou People’s Hospital, Taizhou, China 2 Department of Oncology, Taizhou People’s Hospital, Taizhou, China Studies in the past decades have uncovered an ...

Biologists discovered that a scaffolding protein called TCOF1 is responsible for the formation of a biomolecular condensate called the fibrillar center, which forms within the cell nucleolus. Inside ...

An essential component of living cells, the nucleolus underwent a major evolutionary shift around 300m years ago. Scientists have solved an age-old mystery in biology by discovering a protein found in ...