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Mendelian randomization uses genetic variants robustly associated with modifiable exposures to generate evidence for potential interventions which could produce health benefits. The IEU has expertise ...

A major goal of epidemiology is to reduce the burden of disease in populations through interventions that target causal determinants of disease risk. Although observational studies, such as ...

ATP citrate lyase is an enzyme in the cholesterol–biosynthesis pathway upstream of 3-hydroxy-3-methylglutaryl–coenzyme A reductase (HMGCR), the target of statins. Whether the genetic inhibition of ATP ...