Ribonucleotides incorporated during DNA replication are removed by RNase H2–dependent ribonucleotide excision repair (RER). In RER-defective yeast, topoisomerase 1 (Top1) incises DNA at unrepaired ...

Proceedings of the National Academy of Sciences of the United States of America, Vol. 113, No. 21 (May 24, 2016), pp. 5916-5921 (6 pages) DNA replication occurs semidiscontinuously due to the ...

As DNA strands ravel and unravel in an intricate dance, one notable event takes center stage: replication. This process is essential to life, but the finer details of its orchestrated steps are still ...

DNA replication is a basic function of living organisms, allowing cells to divide and multiply, all while maintaining the genetic code and proper function of the original cell. The process, or ...

Accurate transmission of the genetic information requires complete duplication of the chromosomal DNA each cell division cycle. However, the idea that replication forks would form at origins of DNA ...

Undergraduate biology students could be forgiven for thinking that scientists have DNA replication all figured out. After all, textbooks present the models of replication so matter-of-factly that it's ...

Humans and baker's yeast have more in common than meets the eye, including an important mechanism that helps ensure DNA is copied correctly, reports a pair of studies published in the journals Science ...

Half a century ago, scientists Jim Watson and Alexey Olovnikov independently realized that there was a problem with how our DNA gets copied. A quirk of linear DNA replication dictated that telomeres ...

Our longest running program was directed toward understanding the enzymology of DNA replication with primary focus on a prototypical cellular replicase, the DNA polymerase III holoenzyme. Because of ...

Humans and baker’s yeast have more in common than meets the eye, including an important mechanism that helps ensure DNA is copied correctly, reports a pair of studies published in the journals Science ...