In genomewide linkage scans for complex diseases involving many loci with small genetic effects, it may be the case that no loci reach conventional statistical significance. A complementary method of ...

In this study, we used computer simulation of simple and complex models to ask: (1) What is the penalty in evidence for linkage when the assumed gene frequency is far from the true gene frequency? (2) ...

It is believed that the main advantage of affected sib-pair tests is that their application requires no information about the underlying genetic mechanism of the disease. However, here it is proved ...

Amyotrophic lateral sclerosis is a progressive neurologic disorder that commonly results in paralysis and death. Despite more than a century of research, no cause of, cure for, or means of preventing ...

For a phase-unknown nuclear family, we show that the likelihood and lod score are unimodal, and we describe conditions under which the maximum occurs at recombination fraction θ = 0, θ = ½, and 0 < θ ...

MINNEAPOLIS (AP) — Robin Lod scored the fastest goal in franchise history, Ethan Finlay also had a goal and Minnesota United beat the Houston Dynamo 2-0 on Saturday night. Lod slipped behind the ...

Robin Lod scored the fastest goal in franchise history, Ethan Finlay also had a goal and Minnesota United beat the Houston Dynamo 2-0. Lod slipped behind the defense and put away a one-touch shot — ...

ST PAUL, Minn. — Robin Lod scored the fastest goal in franchise history, Ethan Finlay also had a goal and Minnesota United beat the Houston Dynamo 2-0. Lod slipped behind the defense and put away a ...