Surprisingly, forcing an acceleration of replication forks led to miscoordination between genome replication completion and cell cycle progression. Dr. Tsubouchi concludes, "We propose that slow ...

Replication Fork Reversal PARP PARylation activity is not required to form reversed forks, but it promotes the accumulation of regressed forks by inhibiting RECQ1 fork restoration activity, thus ...

Mouse ES cells present active origin firing and replication forks that progress slowly throughout S phase. These features are integral aspects of genome replication ensuring genome integrity in ES ...

DNA is constantly damaged by radiation, chemicals, and our metabolism. Cells have developed sophisticated ways to detect and repair DNA damage, including the Fanconi Anaemia pathway which repairs DNA ...

New research reveals that triggering a cell’s DNA damage response could be a promising avenue for developing novel treatments against several rare but devastating viruses for which no antiviral ...

Mouse ES cells present active origin firing and replication forks that progress slowly throughout S phase. These features are integral aspects of genome replication ensuring genome integrity in ES ...

Reactive oxygen species (ROS) were long regarded as harmful by-products of mitochondrial metabolism, but growing evidence—including our own—shows that ROS also signal to core processes such as ...