From the Wihuri Research Institute (R.O., P.T.K., P.L., M.O.P.) and the Department of Bacteriology and Immunology, University of Helsinki, and Helsinki University ...

Ultralarge von Willebrand factor (vWF) strings are secreted by, and anchored to, stimulated human endothelial cells. A disintegrin and metalloprotease with thrombospondin domains-type 13 cleaves the ...

Factor H (FH) is the key regulator of the alternative pathway of complement. The carboxyl‐terminal domains 19–20 of FH interact with the major opsonin C3b, glycosaminoglycans, and endothelial cells.

Cutaneous squamous cell carcinoma (cSCC) is a common form of skin cancer with an estimated 750,000 cases diagnosed annually in the United States. Most cases are successfully treated with a simple ...

Objective: Renal thrombotic microangiopathy (TMA) is associated with complement overactivation and poor outcome in patients with lupus nephritis (LN). The role of genetic makeup of complement system ...

Immune protection by the complement system critically depends on assembly of C3 convertases on the surface of pathogens and altered host cells. These short‐lived protease complexes are formed through ...

This important work advances our understanding of factors influencing efficacy assessments and biomarker viability for complement-directed gene therapy against age-related macular degeneration. The ...

After mild traumatic brain injury (TBI), a molecule called complement factor C1q may play a role in the secondary effects of brain injury, such as sleep disruption, epileptic activity, and ...

The complement system is a crucial component of the innate immune response in humans. In this study, we report the characterization of an autotransporter protease of Neisseria meningitidis named NalP.

Copyright: © 2001 Elsevier Ltd. Published by Elsevier Ltd. The clinical picture of HUS related to factor H abnormality has emerged in two ways. The first was through ...