DNA replication is a fundamental process essential for bacterial growth and survival. Initiation begins at the chromosomal origin (oriC), where the conserved initiator protein DnaA assembles into an ...

Scientists have uncovered how DnaA, the master key to DNA replication, opens the door to bacterial growth. This breakthroughpaves the way for new antibiotics to combat the rising tide of antibiotic ...

Cell division is fundamental for life, allowing organisms to grow, repair tissues, and reproduce. For a cell to divide, all the DNA inside the cell (the genome) must first be copied, in a process ...

S. aureus has been identified as a common secondary bacterial coinfection agent for different respiratory viruses. Several investigations have revealed that coinfection with the influenza A virus (IAV ...

In this multi-disciplinary work employing single-molecule TIRF microscopy, chemical biology and structural biology, Dr Aravindan Ilangovan, Reader in Structural Biology, and his team at School of ...

E. coli divides faster than it can replicate its genome, while simultaneously expressing its genes. Scientists recently revealed the intricate molecular coordination that makes this possible. “It’s as ...

BioRxiv (2023) PubMed PMID: 37546940; PubMed Central PMCID: PMC10402079. The mammalian innate immune system uses cyclic GMP–AMP synthase (cGAS) to synthesize the cyclic dinucleotide 2′,3′-cGAMP during ...

As antibiotic-resistant infections rise and are projected to cause up to 10 million deaths per year by 2050, scientists are looking to bacteriophages, viruses that infect bacteria, as an alternative.

Nobody wants to be average. But for a long time, scientists have found it convenient to think of bacterial cells as just that: "average." Researchers have traditionally relied on population-level ...