The classical pathway is activated by C1q-mediated recognition of the target. Further activation of this pathway causes C4b and its cleavage product iC4b to accumulate in the tissues. C4b binds to C2 ...

7 KU Leuven, Skeletal Biology and Engineering Research Centre, Department of Development and Regeneration, Leuven, Belgium 8 KU Leuven, Skeletal Biology and Engineering Research Centre, Department of ...